Endocrine Abstracts

A 32 year old man with a history of epilepsy since childhood presented in 1992 with a grand mal seizure and clinical features of tuberous sclerosis (TSC). One year later he was referred with classical Cushingoid features. His serum Na was 140 mmol/l, K 3.4 mmol/l, 9 AM cortisol 1018 nmol/l with lack of diurnal variation and ACTH 42-50 ng/l. Urinary cortisol: 797 nmol/24 h. After overnight, low and high dose dexamethasone suppression, cortisol was 1018, 1154, and 62 nmol/l resp...

Introduction: TSH secreting pituitary adenomas (TSHomas) are often large and locally invasive. Following trans-sphenoidal surgery (TSS) patients frequently require adjuvant treatment with either anti-thyroid medication or somatostatin analogue therapy.Objective: To evaluate the value of a single subcutaneous octreotide test dose in predicting the the response to long term treatment in 5 patients with TSHomas.Methods: Five consecutive patients presenting 2000-02 were ev...